Authors: |
Simone Balocco, CREATIS, Université Claude Bernard Lyon 1, CNRS UMR 5515, INSERM U630, Lyon, France; Olivier Basset, CREATIS, INSA Lyon, CNRS UMR 5515 INSERM U630, Lyon, France; Francesco Guidi, Piero Tortoli, Università di Firenze, Italy; Christian Cachard, CREATIS, Université Claude Bernard Lyon 1, CNRS UMR 5515, INSERM U630, Lyon, France |
Abstract: |
Ultrasound Contrast Agents (UCA) are widely used for the diagnosis of cardiovascular diseases. They consist of shell encapsulated microbubbles which, when injected in blood, increase the blood/tissue radio in ultrasound (US) medical images. A simple experimental set-up is used to obtain M-mode images in which each microbubble describes a trace of variable brightness position and slope. A Kalman filter model allows an iterative estimation of the instantaneous values of variables such as the bubble position, velocity and acceleration, in a discrete time process. The accuracy of the method has been evaluated on artificial images reporting different phenomena: trace crossing, intensity variation, sudden interruption and different background noise levels. In most cases, the traces have been detected with a mean error lower than one pixel |