| Paper: | BIO-L2.1 | ||
| Session: | Bioinformatics and Genomics | ||
| Time: | Friday, May 19, 10:00 - 10:20 | ||
| Presentation: | Lecture | ||
| Topic: | Bio Imaging and Signal Processing: Bioinformatics, genomics, and proteomics | ||
| Title: | On Limits of Performance of DNA Microarrays | ||
| Authors: | Haris Vikalo, Babak Hassibi, Arjang Hassibi, California Institute of Technology, United States | ||
| Abstract: | DNA microarray technology relies on the hybridization process which is stochastic in nature. Probabilistic cross-hybridization of non-specific targets, as well as the shot-noise originating from specific targets binding, are among the many obstacles for achieving high accuracy in DNA microarray analysis. In this paper, we use statistical model of hybridization and cross-hybridization processes to derive a lower bound (viz., the Cramer-Rao bound) on the minimum mean-square error of the target concentrations estimation. A preliminary study of the Cramer-Rao bound for estimating the target concentrations suggests that, in some regimes, cross-hybridization may, in fact, be beneficial---a result with potential ramifications for probe design, which is currently focused on minimizing cross-hybridization. | ||
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